beta-catenin|Catenin : Clark Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
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beta-catenin,
Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is a dual function protein , involved in regulation and coordination of cell–cell adhesion and gene transcription .
Beta catenin is a protein encoded by CTNNB1 gene with dual functions in cell adhesion and Wnt signaling
Importantly, the β-catenin-binding site on α-catenin overlaps with α-catenin’s homodimerization interface, hence α-catenin can bind to adherens junctions only in its monomeric state (resulting in an α-catenin/β-catenin heterodimer) (Drees et al, 2005; Yamada et al, 2005).
Wnt/β-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment. 300 Using a mouse melanoma. Wnt/β-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment. 300 Using a mouse melanoma.
beta-catenin Catenin Wnt/β-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment. 300 Using a mouse melanoma.
Kim et al. demonstrated in their study that persistent stabilization of beta-catenin in the dental mesenchyme leads to premature differentiation of odontoblasts and differentiation of cememtoblasts and induces excessive dentine and cementum formation in vivo and suggested that temporospatial regulation of Wnt/β catenin signaling plays critical .Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability, from Wnt receptors to the cytoplasmic β-catenin destruction complex, and nuclear machinery that mediates β .beta-cateninThe first two catenins that were identified [2] became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin). [ 3 ] β-Catenin binds directly to the cytoplasmic tail of classical cadherins.
beta-catenin|Catenin
PH0 · β catenin in health: A review
PH1 · Wnt/β
PH2 · Wnt/beta
PH3 · The regulation of β
PH4 · The many faces and functions of β
PH5 · Pathology Outlines
PH6 · Catenin beta
PH7 · Catenin